Effect of soya on serum lipids in postmenopausal women with hypercholesterolemia referred to Assali hospital in Khorramabad

Introduction: Cardiovascular diseases (CVD) are among the major problems in post- menopausal women. One of the important reasons for CVD is atherosclerosis and it is supposed that estrogen prevent women from atherosclerosis. Soya contains, isoflavones suh as Genistein and Daidzen, that subelassed phytoestrogens. The present study was carried out to determine the effects of soya on hypercholesterlemic postmenopausal women’s lipid and lipoproteins levels in serum. Materials and Methods: This study is a clinical trial on 100 hypercholesterolemic postmenopausal women, undergoing to check in Khorramabab Assali hospital in 2002. We divided the patients into two groups randomly. The first group received capsule containing 500 mg soya, at the does, 2 gr/day, SID, and second group received placebo capsule, for 12 weeks. The research was a triple blind study. We took blood sample for laboratory measurement prior and, as well as 12 weeks after the treatment. Differences between two groups were analyzed using SPSS software. Findings: Results of the study showed that the mean of serum cholesterol, TG, HDL and LDL were not significant different between soya and placebo groups, before treatment and 12 weeks after the treatment (PV>0.05). These findings showed that soya has no significant effect on CHOL, TG, HDL and LDL levels in hyper cholesterolemic postmenopausal women. Conclusion: Regarding the above mentioned results soya can not be a good substitution for estrogen.